Vivani Medical (VANI) on Wednesday, unveiled preclinical findings regarding the weight loss effects of NPM-115, its miniature exenatide subdermal implant developed for chronic weight management, shedding light on its potential impact.<\/p>\n\n\n\n
In a study involving high-fat diet-induced obese mice, NPM-115 demonstrated a remarkable weight reduction of approximately 20% compared to a control group with sham implants over a 28-day treatment period. The efficacy of NPM-115 rivaled that of Novo Nordisk A\/S\u2019s Ozempic\/Wegovy injections (semaglutide), a popular weight loss treatment.<\/p>\n\n\n\n
Both NPM-115 and semaglutide were administered at supratherapeutic doses to maximize their weight loss potential. Additionally, a separate study in healthy rats showcased the promising weight-reducing effects of NPM-119, a single-administration exenatide implant designed for type 2 diabetes treatment, with sustained release over 15 weeks.<\/p>\n\n\n\n
NPM-115’s higher-dose formulation, akin to NPM-119, suggests enduring weight loss effects, affirming its potential in future clinical trials. Moreover, Vivani Medical disclosed plans for NPM-139, featuring semaglutide, as a once-yearly implant for chronic weight management, signaling a strategic shift towards obesity-focused implants.<\/p>\n\n\n\n
The findings underscore the promising role of exenatide in weight management, hinting at a potential paradigm shift in obesity treatment. Notably, existing exenatide products face limitations in adherence and dosing, presenting an opportunity for innovative implant-based solutions in the field of weight management.<\/p>\n","protected":false},"excerpt":{"rendered":"
Vivani Medical (VANI) released preclinical data on weight loss effects for NPM-115 Vivani Medical (VANI) on Wednesday, unveiled preclinical findings regarding the weight loss effects of NPM-115, its miniature exenatide subdermal implant developed for chronic weight management, shedding light on its potential impact. In a study involving high-fat diet-induced obese mice, NPM-115 demonstrated a remarkable […]<\/p>\n","protected":false},"author":1,"featured_media":1544,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","jnews-multi-image_gallery":[],"jnews_single_post":{"subtitle":"","format":"standard","video":"","gallery":"","source_name":"","source_url":"","via_name":"","via_url":"","override_template":"0","override":[{"template":"8","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar-narrow","sidebar":"author","second_sidebar":"single-right","sticky_sidebar":"1","share_position":"top","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"1","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"1","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"0","zoom_button_out_step":"2","zoom_button_in_step":"3","show_post_tag":"1","show_prev_next_post":"1","show_popup_post":"1","number_popup_post":"1","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-500","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"","hide":""},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"jnews_post_split":{"enable_post_split":"0","post_split":[{"template":"1","tag":"h2","numbering":"asc","mode":"normal","first":"0","enable_toc":"0","toc_type":"normal"}]}},"categories":[307,319,358],"tags":[],"coauthors":[453],"_links":{"self":[{"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/posts\/1545"}],"collection":[{"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/comments?post=1545"}],"version-history":[{"count":1,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/posts\/1545\/revisions"}],"predecessor-version":[{"id":1546,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/posts\/1545\/revisions\/1546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/media\/1544"}],"wp:attachment":[{"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/media?parent=1545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/categories?post=1545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/tags?post=1545"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/stoxpo.com\/index.php\/wp-json\/wp\/v2\/coauthors?post=1545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}