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Home Companies Micro-Cap
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Conduit Pharmaceuticals Secures Exclusive Licensing Agreement with AstraZeneca for Novel Therapeutics

byLiliana Vida
August 8, 2024
in Micro-Cap, Pharmaceuticals
Reading Time: 4 mins read
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Phase II Trials Set to Begin on Glucokinase Activators and Myeloperoxidase Inhibitor Targeting Autoimmune Disorders and Male Infertility

Conduit Pharmaceuticals (CDT) has announced a significant step forward in its mission to develop innovative treatments for unmet medical needs. The company has entered into an exclusive licensing agreement with pharmaceutical giant AstraZeneca, securing the rights to develop three promising compounds: AZD1656 and AZD5658, both HK-4 glucokinase activators, and AZD5904, a myeloperoxidase (MPO) inhibitor. These assets, which have already shown favorable preclinical and Phase I data, will be advanced by Conduit into Phase II clinical trials targeting autoimmune disorders and idiopathic male infertility.

A Strategic Alliance with AstraZeneca

Under the terms of the agreement, AstraZeneca grants Conduit an exclusive license to AZD1656 and AZD5658 for all human indications, as well as to AZD5904 for use in treating idiopathic male infertility. This partnership reflects Conduit’s strategic approach to drug development, which involves acquiring assets that have already undergone substantial preclinical and clinical testing, thereby reducing the time and resources needed to bring new treatments to market.

As part of the deal, AstraZeneca will receive shares of common stock in Conduit and a share of sublicense revenues, including upfront payments, milestones, and royalties from future partnerships. This arrangement underscores the mutual benefit both companies seek from the collaboration. AstraZeneca will also transfer valuable know-how related to the compounds and provide Conduit with certain quantities of AZD1656, AZD5658, and AZD5904 from its inventory, further supporting Conduit’s development efforts.

Fast-Tracking Development of Promising Therapeutics

Conduit’s initial focus will be on advancing AZD1656 and AZD5658 through Phase II clinical trials in 2024. These compounds target autoimmune disorders, a category of diseases that impact an estimated 10% of the global population. Autoimmune disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis, represent a significant area of unmet medical need, with patients often requiring new and more effective treatment options.

AZD1656 and AZD5658, as HK-4 glucokinase activators, have shown potential in modulating glucose levels and influencing immune responses, making them promising candidates for addressing autoimmune conditions. The existing data from AstraZeneca’s Phase I trials provides a solid foundation for Conduit to build upon as it prepares for Phase II studies.

In parallel, Conduit will explore the potential of AZD5904, a myeloperoxidase inhibitor, in treating idiopathic male infertility. Myeloperoxidase is an enzyme linked to oxidative stress and inflammation, which can contribute to various conditions, including infertility. The development of AZD5904 could offer a novel therapeutic approach for men facing infertility, a condition with limited treatment options currently available.

A Unique Business Model

Conduit Pharmaceuticals has carved out a distinct niche in the biopharmaceutical industry by focusing on assets that are already in the later stages of development. Unlike traditional biotech companies that take compounds from discovery through commercialization, Conduit’s strategy involves accelerating the development of assets through Phase II trials. Upon achieving positive results, the company intends to seek exits through third-party license opportunities, thereby minimizing risk while maximizing potential returns.

This business model allows Conduit to bring new therapies to patients more quickly, addressing urgent medical needs without the prolonged timelines associated with early-stage drug development. By leveraging the extensive work already done by AstraZeneca on these compounds, Conduit is positioned to expedite the process of getting these therapies into clinical use.

Looking Ahead

The exclusive licensing agreement with AstraZeneca marks a pivotal moment for Conduit Pharmaceuticals. With access to AZD1656, AZD5658, and AZD5904, Conduit has secured a portfolio of compounds with the potential to make a significant impact on patients’ lives. The company’s commitment to advancing these assets into Phase II trials demonstrates its confidence in their therapeutic potential and its dedication to addressing the needs of patients with autoimmune disorders and idiopathic male infertility.

Dr. David Tapolczay, Chief Executive Officer of Conduit, expressed optimism about the partnership, stating, “The potential of these assets to become important first-in-class medicines for patients is promising. Given the data from AstraZeneca’s clinical trials, we believe there is a strong rationale to initiate Phase II studies in multiple indications to progress to commercialization of these assets.”

As Conduit prepares to initiate these trials in 2024, the biopharmaceutical community will be closely watching the outcomes, anticipating the next steps in the journey of these novel therapeutics. With a strategic partner like AstraZeneca and a clear pathway to development, Conduit is poised to make significant strides in the treatment of autoimmune disorders and male infertility.

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