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BioNTech and Autolus Forge Strategic Partnership to Propel CAR-T Cell Therapy Pipeline

Accelerating Cancer Therapy: BioNTech and Autolus Join Forces to Revolutionize CAR-T Pipeline

byLiliana Vida
February 22, 2024
in Healthcare, Pharmaceuticals
Reading Time: 2 mins read
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In a significant development within the biopharmaceutical sector, BioNTech SE and Autolus Therapeutics plc have announced a strategic collaboration aimed at accelerating the advancement of their autologous CAR-T programs towards commercialization, subject to regulatory approvals. This collaboration revealed on February 8, 2024, signifies a substantial step forward for both companies as they join forces to expedite the development and expansion of their respective pipelines.

The collaboration entails several key elements:

Firstly, BioNTech will utilize Autolus’ state-of-the-art manufacturing facilities to fast-track the development of BNT211, targeting CLDN6+ tumors. This strategic move not only enhances BioNTech’s manufacturing capacity but also expedites the pathway to pivotal trials for BNT211.

Secondly, BioNTech will make a significant financial investment in Autolus, injecting $200 million into the company. This financial infusion underscores BioNTech’s commitment to the partnership and its confidence in Autolus’ potential to deliver innovative therapies.

Thirdly, the agreement grants BioNTech access to Autolus’ proprietary technologies, including precise cell targeting tools. This access will bolster BioNTech’s efforts in developing in vivo cell therapy and antibody-drug conjugate candidates, potentially broadening the scope of their therapeutic offerings.

Dr. Christian Itin, CEO of Autolus, emphasized the collaborative opportunity to accelerate pipeline programs and achieve cost efficiencies. He underscored the significance of advancing obe-cel’s path in adult acute lymphoblastic leukemia, aiming to address an unmet medical need in the field.

Similarly, Prof. Ugur Sahin, M.D., CEO and Co-Founder of BioNTech, expressed optimism about the collaboration’s potential to drive progress in cancer therapy. He highlighted the strategic importance of accessing Autolus’ manufacturing infrastructure and technological expertise.

Overall, the partnership between BioNTech and Autolus represents a concerted effort to leverage synergies, optimize resources, and ultimately, advance innovative therapies for patients in need. As both companies navigate the complexities of drug development, the broader medical community awaits eagerly for the transformative impact of this strategic alliance.

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