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chemistry

Alpha Cognition Secures $44 Million Licensing Deal with CMS for ZUNVEYL in Asia-Pacific

byLiliana Vida
January 8, 2025
in Pharmaceuticals, Small-Cap
Reading Time: 4 mins read
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Agreement Paves the Way for Advanced Alzheimer’s Treatment in China and Beyond

Alpha Cognition (ACOG), a biopharmaceutical company at the forefront of developing therapeutics for neurodegenerative disorders, has announced a landmark licensing agreement worth $44 million with China Medical System Holdings Limited (CMS). The deal grants CMS the exclusive rights to develop, manufacture, and commercialize ZUNVEYL (benzgalantamine) in Asia (excluding Japan), Australia, and New Zealand.

A New Frontier for Alzheimer’s Treatment

ZUNVEYL, a next-generation acetylcholinesterase inhibitor, is FDA-approved in the United States for the treatment of mild-to-moderate Alzheimer’s disease. Its mechanism targets cognitive decline by enhancing the communication between nerve cells, offering hope to millions of Alzheimer’s patients globally.

The agreement underscores the growing demand for advanced Alzheimer’s treatments in the Asia-Pacific region, particularly in China, where an estimated 50 million people suffer from the disease. With CMS’s extensive experience in navigating the region’s complex regulatory and commercial environment, this partnership is expected to accelerate the availability of ZUNVEYL in markets where Alzheimer’s cases are rising rapidly.

“We are excited to partner with CMS to distribute ZUNVEYL,” said Michael McFadden, CEO of Alpha Cognition. “CMS’s expertise in developing and commercializing central nervous system (CNS) therapies in China makes them the ideal partner to navigate these territories. Together, we aim to bring meaningful relief to millions of patients and their families.”

Deal Terms and Strategic Implications

The agreement includes $6 million in upfront payments, structured in tranches, alongside development and commercial milestone payments. Alpha Cognition will also receive royalties on net sales of ZUNVEYL within the licensed territories. This financial structure not only strengthens ACI’s revenue potential but also ensures that the treatment reaches patients in some of the most underserved Alzheimer’s markets globally.

Under the partnership, CMS will assume responsibility for regulatory filings, development activities, manufacturing, and marketing of ZUNVEYL in the agreed-upon regions. This comprehensive approach will leverage CMS’s established infrastructure and capabilities in China and other territories.

A Strategic Partnership

For CMS, the collaboration marks another step in its commitment to bringing innovative treatments to China and surrounding regions. Known for its strong product lifecycle management, CMS has a proven track record in developing and commercializing CNS therapies, making it a natural fit for the ZUNVEYL initiative.

“ZUNVEYL represents a significant addition to our CNS portfolio,” noted a representative from CMS. “We are committed to ensuring that this groundbreaking treatment reaches the patients who need it most, particularly in China, where the burden of Alzheimer’s disease continues to grow.”

Global Ambitions for ZUNVEYL

While the CMS partnership focuses on the Asia-Pacific market, Alpha Cognition remains on track to launch ZUNVEYL in the United States in the first quarter of 2025. The company has planned a corporate update and launch strategy presentation on January 28, 2025, to outline its roadmap for ZUNVEYL’s entry into the U.S. market.

The dual-track strategy highlights Alpha Cognition’s ambition to make ZUNVEYL a globally recognized treatment for Alzheimer’s disease. By securing this licensing agreement, ACI not only expands its international footprint but also bolsters its financial position to support further innovation in neurodegenerative therapies.

The Future of Alzheimer’s Treatment

The deal comes at a critical time when Alzheimer’s disease is becoming an increasingly urgent global health challenge. In China alone, the aging population is driving a sharp rise in Alzheimer’s diagnoses, creating a pressing need for effective treatments like ZUNVEYL.

As the partnership unfolds, the combination of Alpha Cognition’s innovative drug development and CMS’s expertise in commercialization is poised to transform the landscape of Alzheimer’s treatment in the Asia-Pacific region.

Alpha Cognition’s CEO Michael McFadden captured the essence of the partnership, saying, “This is a pivotal moment for ZUNVEYL. Together with CMS, we are not only addressing a significant unmet need but also setting the stage for a future where effective Alzheimer’s treatments are accessible to patients worldwide.”

The $44 million licensing agreement is more than a business milestone—it’s a beacon of hope for millions of families grappling with the devastating impact of Alzheimer’s disease. As the partnership takes shape, all eyes will be on the Asia-Pacific region, where the promise of ZUNVEYL may soon become a reality.

Read the original press release here

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